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Madotine (Paroxetine)
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Madotine

Madotine is the most potent inhibitor of the reuptake of serotonin of all selective serotonin reuptake inhibitors (SSRIs) and has been studied in many randomised controlled trials (RCTs).

Other names for this medication:
Baxidep, Curetin, Leparox, Liveli, Madotine, Mirdox, Onbixin, Oxitine, Panex, Paradise, Pardep, Paromec, Paronex, Parotin, Paroxet, Paroxetine, Paroxi, Partin, Paxidep, Paxiza, Petin, Pexep, Pexeva, Praxo, Qxitine, Raxit, Sarolife, Serotin

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Also known as: Paroxetine

Description

Madotine (paroxetine) is an antidepressant that belongs to group of drugs called selective serotonin reuptake inhibitors (SSRIs). Paroxetine affects chemicals in the brain that may be unbalanced in people with depression, anxiety, or other disorders.

Madotine is used to treat depression, including major depressive disorder.

Madotine is also used to treat panic disorder, obsessive-compulsive disorder (OCD), anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).

Dosage

Take Madotine exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Swallow the Madotine CR extended-release tablet whole and do not crush, chew, or break the tablet.

Shake the Madotine oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

Do not stop using Madotine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture, heat, and light.

Detailed Madotine dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Madotine CR can be fatal.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Madotine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Madotine if you are allergic to paroxetine, or if you are also taking pimozide or thioridazine.

Do not use an MAO inhibitor within 14 days before or 14 days after you take paroxetine. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. After you stop taking Madotine you must wait at least 14 days before you start taking an MAO inhibitor.

To make sure Madotine is safe for you, tell your doctor if you have:

heart disease, high blood pressure, or a stroke; liver or kidney disease; a bleeding or blood clotting disorder; seizures or epilepsy; bipolar disorder (manic depression), drug addiction, or suicidal thoughts; narrow-angle glaucoma; or low levels of sodium in your blood.

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with paroxetine and cause a serious condition called serotonin syndrome.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking an SSRI antidepressant such as Madotine during pregnancy may cause serious lung problems or other complications in the baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine without your doctor's advice.

You should not breastfeed while using this medicine.

Madotine is not approved for use by anyone younger than 18 years old.

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Integrated cerebral protection: combined antegrade and retrograde cerebral perfusion during deep hypothermic circulatory arrest. The structure of the core polyol of the ether lipids from Sulfolobus acidocaldarius. Rats (5 per group) were given 200 mg/kg (human dose equivalent of approximately 1,300 mg/m(2)) of amifostine either IV or SC, and their head and neck regions were exposed to 15.3 Gy of gamma radiation 0.5, 2, 4, and 8 hours after amifostine administration. The age at onset of PCT was significantly lower in HCV-positive patients than in HCV-negative patients. We have typed 25 homozygous B lymphoblastoid cell lines, defined as reference panel during the Xth International Histocompatibility Workshop, using PCR (Polymerase Chain Reaction) and oligonucleotidic probes recognizing sequences of DQA and DQB genes. In contrast, changes in the shape or orientation of these figures, which leave their component lines vertical and hlorizontal, do not reliably aid grouipinig. It is hypothesized that the electrophysiological result of this facilitation will be an increased energy of the event related potential (ERP) resulting from the interaction between the visual and auditory processes. Future studies are necessary to establish the efficacy of this overground locomotor training program and to differentiate among potential mechanisms contributing to enhanced walking performance in people with iSCI after overground locomotor training. Apoptosis of human gastric cancer cell line MGC-803 induced by glycyrrhiza uralensis extract. Adjuvant Chemotherapy is Indicated in Patients with Lower Grade Glioma.

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These results indicate that lesions to the MC of turtles and to the LP of goldfish, like hippocampal lesions in mammals and birds, selectively impair map-like memory representations of the environmental space. administration of cis-diammine-platinum(II)-lactate cis-diammine-platinum(II)-lactate, L cis-diammine-platinum(II)-dilactate trans-dihydroxy-cis-dichlorodiammine-platinum(IV), the LD50 values have been calculated to range between 80 and 130 mg/kg in mice, and between 22 and 45 mg/kg in rats. Levels of TG(R) mRNA and protein increased only in the retinal ganglion cells (RGCs) between 10 and 40 days after optic nerve transection. In the presence of a liquid crystalline (bilayer) phase, up to 1 (oleate) or 2 (palmitate) mol of FA were bound/mol of L-FABP, but in the presence of a crystalline phase (1:1 acid-soap), up to 3 mol of palmitate were bound/mol of L-FABP (all at pH 7.2). Competitive gene set analysis is a standard exploratory tool for gene expression data. The phylogeny of selected gasteromycetes and hymenomycetes was inferred from partial nuclear large subunit rDNA (nuc-lsu, 28S) sequences, delimited by primers LR0R and LR5. Fifty-six patients were stimulated with the multidose antagonist protocol and 12 with the long agonist protocol. Chinese hamster ovary (CHO) cells at pH 7.3 and low-pH-resistant (PHV2) cells at pH 6.6 were studied. In 2-unsubstituted 1-naphthamides bearing branched N-substituents, most conformational changes about the amide group were by correlated rotation, though uncorrelated Ar-CO rotation also occurred to some extent. This is one of only a few case reports on mesh migration presenting as a suspected bladder malignancy.

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