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Madotine (Paroxetine)

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Madotine is the most potent inhibitor of the reuptake of serotonin of all selective serotonin reuptake inhibitors (SSRIs) and has been studied in many randomised controlled trials (RCTs).

Other names for this medication:
Baxidep, Curetin, Leparox, Liveli, Madotine, Mirdox, Onbixin, Oxitine, Panex, Paradise, Pardep, Paromec, Paronex, Parotin, Paroxet, Paroxetine, Paroxi, Partin, Paxidep, Paxiza, Petin, Pexep, Pexeva, Praxo, Qxitine, Raxit, Sarolife, Serotin

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Also known as: Paroxetine


Madotine (paroxetine) is an antidepressant that belongs to group of drugs called selective serotonin reuptake inhibitors (SSRIs). Paroxetine affects chemicals in the brain that may be unbalanced in people with depression, anxiety, or other disorders.

Madotine is used to treat depression, including major depressive disorder.

Madotine is also used to treat panic disorder, obsessive-compulsive disorder (OCD), anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).


Take Madotine exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Swallow the Madotine CR extended-release tablet whole and do not crush, chew, or break the tablet.

Shake the Madotine oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

Do not stop using Madotine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture, heat, and light.

Detailed Madotine dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Madotine CR can be fatal.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Madotine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Madotine if you are allergic to paroxetine, or if you are also taking pimozide or thioridazine.

Do not use an MAO inhibitor within 14 days before or 14 days after you take paroxetine. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. After you stop taking Madotine you must wait at least 14 days before you start taking an MAO inhibitor.

To make sure Madotine is safe for you, tell your doctor if you have:

heart disease, high blood pressure, or a stroke; liver or kidney disease; a bleeding or blood clotting disorder; seizures or epilepsy; bipolar disorder (manic depression), drug addiction, or suicidal thoughts; narrow-angle glaucoma; or low levels of sodium in your blood.

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with paroxetine and cause a serious condition called serotonin syndrome.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking an SSRI antidepressant such as Madotine during pregnancy may cause serious lung problems or other complications in the baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine without your doctor's advice.

You should not breastfeed while using this medicine.

Madotine is not approved for use by anyone younger than 18 years old.

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Understand the concept of minimal sclerosant concentration and how it can help the physician to choose sclerosing solution concentrations to minimize risks. Pulmonary arterial dilatation in pulmonary hypertension: prevalence and prognostic relevance. In this study, the variation in PID was quantified systematically on a reference set of 1028 alignments generated by comparison of the protein three-dimensional structures. Characterization of the anticoagulant activities from a Brazilian arrow poison. Time-resolved images of the cerebral transit of paramagnetic contrast agent were acquired using a new ultrafast NMR imaging technique and a novel mechanism of image contrast based on microscopic changes in tissue magnetic susceptibility. There are currently major gaps between the goals and objectives of competency frameworks such as CanMEDS and the actual contents of medical curricula.

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Purification and characterization of recombinant squalene epoxidase. The adherence of pyelonephritic Escherichia coli isolates to mammalian host cells is mediated by the P-pili structures on the bacterial surface. Images from biopsies were digitized and cell nuclei features were extracted. The measurement repeatabilities of tomographic thicknesses of intraretinal layers are comparable using both hemispheric and ETDRS partitions in volumetric data combined with the commercially available segmentation software. The TBA models were examined for validity by comparing TBA to the corresponding chronological age (CA) with clinical risk factors. Changes in the distribution pattern of chloride ions were studied in the embryonic chicken retinal pigment epithelium (RPE), chloride ions being deposited as silver chloride (AgCl) in the RPE and observed by electron microscope. Yi migrants have substantially higher proportion of overweight and obese individuals, as well as individuals affected by ISH, IDH, and SDH, than do Yi farmers. Lymphocyte trafficking is a fundamental aspect of the immune system that allows B and T lymphocytes with diverse antigen recognition specificities to be exposed to various antigenic stimuli in spatially distinct regions of an organism. Ergoferon demonstrated antiviral activity by reducing the severity and duration of the major signs of induced influenza infection. Changes in the prevalence of cigarette smoking and quitting smoking determinants in adult inhabitants of rural areas in Poland between 2003 and 2012.

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Integrated cerebral protection: combined antegrade and retrograde cerebral perfusion during deep hypothermic circulatory arrest. The structure of the core polyol of the ether lipids from Sulfolobus acidocaldarius. Rats (5 per group) were given 200 mg/kg (human dose equivalent of approximately 1,300 mg/m(2)) of amifostine either IV or SC, and their head and neck regions were exposed to 15.3 Gy of gamma radiation 0.5, 2, 4, and 8 hours after amifostine administration. The age at onset of PCT was significantly lower in HCV-positive patients than in HCV-negative patients. We have typed 25 homozygous B lymphoblastoid cell lines, defined as reference panel during the Xth International Histocompatibility Workshop, using PCR (Polymerase Chain Reaction) and oligonucleotidic probes recognizing sequences of DQA and DQB genes. In contrast, changes in the shape or orientation of these figures, which leave their component lines vertical and hlorizontal, do not reliably aid grouipinig. It is hypothesized that the electrophysiological result of this facilitation will be an increased energy of the event related potential (ERP) resulting from the interaction between the visual and auditory processes. Future studies are necessary to establish the efficacy of this overground locomotor training program and to differentiate among potential mechanisms contributing to enhanced walking performance in people with iSCI after overground locomotor training. Apoptosis of human gastric cancer cell line MGC-803 induced by glycyrrhiza uralensis extract. Adjuvant Chemotherapy is Indicated in Patients with Lower Grade Glioma.

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High selective leishmanicidal activity of 3-hydroxy-2-methylene-3-(4-bromophenyl)propanenitrile and analogous compounds. But without a strong background in statistics, it may be difficult to determine the efficacy of the data analytic technique used in the study. Information obtained from risk calculators such as CHA2DS2-VASc and HAS-BLED should be considered before prescribing. Regional differences in the rate of turnover of norepinephrine in the rat brain. PCNA staining and TUNEL assay were performed on kidney sections. To evaluate the feasibility, diagnostic accuracy, and radiation dose of CT coronary angiography (CTCA) in patients with atrial fibrillation (AF) using 320-detector CT.

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These results indicate that lesions to the MC of turtles and to the LP of goldfish, like hippocampal lesions in mammals and birds, selectively impair map-like memory representations of the environmental space. administration of cis-diammine-platinum(II)-lactate cis-diammine-platinum(II)-lactate, L cis-diammine-platinum(II)-dilactate trans-dihydroxy-cis-dichlorodiammine-platinum(IV), the LD50 values have been calculated to range between 80 and 130 mg/kg in mice, and between 22 and 45 mg/kg in rats. Levels of TG(R) mRNA and protein increased only in the retinal ganglion cells (RGCs) between 10 and 40 days after optic nerve transection. In the presence of a liquid crystalline (bilayer) phase, up to 1 (oleate) or 2 (palmitate) mol of FA were bound/mol of L-FABP, but in the presence of a crystalline phase (1:1 acid-soap), up to 3 mol of palmitate were bound/mol of L-FABP (all at pH 7.2). Competitive gene set analysis is a standard exploratory tool for gene expression data. The phylogeny of selected gasteromycetes and hymenomycetes was inferred from partial nuclear large subunit rDNA (nuc-lsu, 28S) sequences, delimited by primers LR0R and LR5. Fifty-six patients were stimulated with the multidose antagonist protocol and 12 with the long agonist protocol. Chinese hamster ovary (CHO) cells at pH 7.3 and low-pH-resistant (PHV2) cells at pH 6.6 were studied. In 2-unsubstituted 1-naphthamides bearing branched N-substituents, most conformational changes about the amide group were by correlated rotation, though uncorrelated Ar-CO rotation also occurred to some extent. This is one of only a few case reports on mesh migration presenting as a suspected bladder malignancy.

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There were no operative complications and 4 of 6 patients were discharged home the day of surgery. Cervical length and delivery outcomes in patients with prophylactic cervical cerclage. To the best of our knowledge, fatal thrombosis of the basilar artery due to a minor head injury has not previously been reported. Sleep and Fatigue Among Seafarers: The Role of Environmental Stressors, Duration at Sea and Psychological Capital. The EMCDDA annual report 2010: the state of the drugs problem in Europe. Changes in the villous pattern of the human jejunum associated with heavy radiation damage. In addition to pharmacological and stimulation based interventions, surgical manipulation of the peripheral nerves and muscles of the extremity can offer functional enhancement for a variety of limb impairments. The other pathway relies on the recognition of a viral RNA element by a virus-encoded protein that interacts with the karyopherin CRM1. Tricuspid valve performance in the systemic circulation is known to have important implications for survival and functional status after univentricular palliation of hypoplastic left heart syndrome (HLHS).

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Y-specific sequences were detected using polymerase chain reaction (PCR) and fluorescent in situ hybridization. Lumbar cutaneous hemangiomas as indicators of tethered spinal cords. Early and late postoperative angiograms demonstrated that this may be a transient phenomenon, and repeated intraoperative films documented that spasm may progress without further direct instrumentation of the involved segment. The functional and anatomical results were assessed 2 months after the second ossiculoplasty and during the most recent out patient clinic. Three masks are needed to produce the surface-relief structure of the DPE with eight quantized levels in depths. The goal of the present study was to characterize these cells and uncover their potential site of origin. The results of further studies on the long-term actions of AM on adrenal growth and differentiation are awaited with interest. Metallurgical aspects of palladium-silver porcelain-bonding alloys. The combined treatment with tunicamycin and TRAIL significantly induced apoptosis, and stimulated caspase-3, -8 and -9 activity, as well as the cleavage of poly (ADP-ribose) polymerase.

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Pinazepam: analytical study of synthesis, degradation, potential impurities. However, renal fumarylacetoacetate hydrolase deficiency is not corrected by OLT, and the long-term prognosis of the nephropathy is not known. A measure of the extent of burn injury based on fluid resuscitation. The baroreflex did not activate glycogen breakdown is evista a chemotherapy drug , whereas nerve stimulation and hemorrhage did, indicating that not only were hepatic nerves not reflexly activated but glucagon and adrenaline levels in plasma were not significantly elevated. Low birth weight in relation to the interval between pregnancies. Estimating incidence of vision-reducing cataract in Africa: a new model with implications for program targets.

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