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Direc (Diazepam)

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Direc is a benzodiazepine (ben-zoe-dye-AZE-eh-peens). It affects chemicals in the brain that may be unbalanced in people with anxiety. Direc is used to treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Direc is sometimes used with other medications to treat seizures. Direc may also be used for purposes not listed in this medication guide.

Other names for this medication:
Almpose, Alpazepam, Alzepam, Anxol, Calmod, Calmpose, Calmtack, Campin, Camrelease, Daize, Depresom, Depsonil, Diaclam, Diazecalm, Diazeco, Diazepam, Dipax, Direc, Dizapam, Dizep, Elcion, Elpam, Elpose, Imilor, Imipam, Imlor, Juniz, Karpam, Lakpam, Neomesmar, Nindral, Nupose, Osopose, Paciquil, Paxum, Peacin, Ralium, Silprex, Sleecalm, Sparlium, Syziral, Verzepam, Vipinta, Zeopse, Zycalm

Similar Products:
Benemid, Dulcolax, Zyrtec, Aldactone, Xanax, Dilantin, Esidrex, Sychozine, Incold, Tininum, Bactocin, Moredrill, Xtram,

Also known as: Diazepam


Direc (diazepam) is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). It is thought that diazepam works by enhancing the activity of certain neurotransmitters in the brain.

Direc is used to treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms and stiffness.

Direc is sometimes used with other medications to treat seizures.


Diazepam is injected into a muscle, or into a vein through an IV. You will receive this injection in a medical or surgical setting. Diazepam injection is for short-term use only.

Diazepam injection is usually given as a single dose just before a surgery or medical procedure. For other conditions, this medicine is usually given until you are able to take medicine by mouth.

You may need to receive only one dose of diazepam if your condition improves after the medicine is given.

When injected into a vein, diazepam must be given slowly. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when this medicine is injected.

After treatment with diazepam injection, you will be watched to make sure the medication is working and does not cause harmful side effects.

Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are in surgery.

Diazepam can make you very drowsy, dizzy, or light-headed. These effects may last longer in older adults. Use caution to avoid falling or accidental injury after you have received diazepam injection. You may need help getting out of bed for at least the first several hours.

Detailed Direc dosage information


Overdose of benzodiazepines is usually manifested by central nervous system depression ranging from drowsiness to coma. In mild cases, symptoms include drowsiness, confusion, and lethargy. In more serious cases, symptoms may include ataxia, diminished reflexes, hypotonia, hypotension, respiratory depression, coma (rarely), and death (very rarely). Overdose of benzodiazepines in combination with other CNS depressants (including alcohol) may be fatal and should be closely monitored.


Store at room temperature away from moisture, heat, and light. After you have stopped using this medicine, flush any unused pills down the toilet.

Keep track of the amount of medicine used from each new bottle. Direc is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Direc are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not be treated with diazepam if you are allergic to it. You may not be able to use diazepam if you have glaucoma.

If possible before you receive diazepam, tell your caregivers if you have ever had:

glaucoma; asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems; kidney or liver disease; mental illness, depression, or suicidal thoughts or behavior; heart disease; or if you have recently used alcohol, sedatives, tranquilizers, or opioid medications.

Diazepam may harm an unborn baby, and generally should not be used during pregnancy. However, status epilepticus is a life-threatening condition and the benefit of receiving this medicine to treat it may outweigh any risk to the unborn baby. Tell your doctor if you become pregnant.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

In an emergency, you may not be able to tell caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you received this medicine.

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A new method of stimulating uterine-placental blood flow, based on regulating venous circulation in the uterus. Introduction to the study of cardiovascular diseases in Puerto Rico. Silencing mitogen-activated protein kinase-activated protein kinase-2 arrests inflammatory bone loss. Evidence that the upstream stimulatory factor and the Sp1 transcription factor bind in vitro to the promoter of the human-growth-hormone gene. Giant hemangioma of the liver revealed by an inflammatory syndrome. Animals were monitored weekly using otomicroscopy until myringotomy closure. The technical and financial hurdles to facilitate clinical acceptance of mAbs are explored and insights into novel technologies and targets that could support more rapid clinical development are offered. Information systems are being utilized in variations research to provide an array of potential variables, to provide measures of the variability inherent in these variables, and to assist with the study of the linkages of patient and provider characteristics with interventions and outcomes. The lack of flexibility of the commercial systems until now forced various FES research teams to develop their own stimulators.

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This seminal finding also highlighted our sparse knowledge about key signalling pathways in colorectal tumours. Compared with the other previously documented cases of prolonged complex partial status epilepticus, this case is notable for its unusual, complicated and severe symptomatology and long duration (three more months) with poor prognosis. The recovery of the cell body may begin shortly after synapses are established, regardless of whether they are correctly or incorrectly targetted. Characterization of respiratory drug delivery with enhanced condensational growth using an individual path model of the entire tracheobronchial airways. In contrast, amino acid substitutions in the central region reduced incisions at the damaged site in the cell-free NER assay, and four of these mutants (K141A, T142A, K167A, and K179A) showed reduced binding to RPA70 but normal binding to damaged DNA. The definition of benefits: from the benefit package to the supply of services.

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After correction for differences in the speed of each stroke, the loss in speed (performance decrement) in the more complex stroke (crawl) was significantly greater than the decrement in the less complex (breast) stroke. Comparative studies on the distribution of heavy metals in the oceans and coastal waters. The extensive infiltration growing patterns of these types of xenografts make them useful models for studying the invasion mechanisms in gliomas. ChemBank is both a data repository and a data analysis environment, facilitating the exploration of chemical and biological information across many different assays and small molecules. Proteins contain amino acid residues essential to structure and function.

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Effects of Ginkgo biloba on dementia: An overview of systematic reviews. These viruses possessed the characteristics of the bovine herpesvirus-3 (BHV-3) group and were indistinguishable by serology and restriction endonuclease analysis from the BHV-3 type strains Movar 33/63 and DN599. In all cases, HMPAO scans showed defects with a quality equivalent to or greater than that demonstrated by CT. Worldwide there are very few independent bodies that produce certified reference materials for phycotoxins, the main producers currently being the National Research Council Canada and the Japanese Food Research Laboratory. In this study, we characterized the development and function of hematopoietic cells in Cdk4(-/-) mice and assessed the response of Cdk4(-/-) mice to allergen challenge. To describe demographic, clinical, behavioral, and psychosocial factors that precipitate admission for exacerbation of heart failure and assess the relationships between precipitating factors and delay before hospitalization, and between delay time and length of hospital stay.

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Catheter ablation (CA) of the triggers or abnormal electrical substrate responsible for VF storm is an important treatment option in rare cases. All three groups were generally inaccurate in their ratings of bodily sensations. Adherence to recommendations for the use of masks among HCWs needs to be evaluated. Physical activity and aerobic fitness in childhood: associated with asthma?. For the EL approach, the fibula and Achilles tendon were palpated and a line parallel to the plantar foot was drawn between the two. Advances in cancer treatment have led to an increase in patient survival. The diameter of the second segmental artery of right upper lobe was larger during diastole period.

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Synergy between T-cell immunity and inhibition of paracrine stimulation causes tumor rejection. Mediators and the anti-thrombotic properties of the vascular endothelium. To construct the retroviral vector containing human micro-dystrophin gene and detect the expression of human micro-dystrophin in mdx mice bone marrow-derived mesenchymal stem cells (MSCs) after retrovirus infection. Nutritional strategies are also frequently considered for enhancing recovery, improving immune function and decreasing oxidative stress. Behavior of colloidal lability reactions of the blood in the course of antitetanus, antipertussis, antityphus and antivariolous vaccinations.

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Comparison of intraoperative arterial pressure and flow with pre- and postoperative exercise blood flow. There follows a defence of naturalism and naturalistic nursing against several objections, including those concerning spirituality, religion, meaning, morality, and alternative sources of knowledge. The majority of new mothers resume intercourse within the first 3 months after delivery. Because four patients developed transient neurological complications that could be attributed to the procedure, the clinical pilot study was terminated. A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies. This need reflects the increasing recognition of occurrence of cardiotoxicities, prior lack of preclinical blood biomarkers for toxic cardiac injury, introduction of troponin as a biomarker, and regulatory and industry drivers.

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During PMA-induced differentiation, the ability of Puralpha to activate the CD11c promoter in U937 cells increases, as does that of Sp1. This treatment relieved the pain and symptoms for 2 years and 6 months. In contrast, treatment of U-937 cells with vinblastine, doxorubicin and m-AMSA resulted in extensive cell death through apoptotic pathways. The TFLs of approximately 200 patients aged between 16 and 55 years presenting with anterior groin pain were evaluated in the course of routine sonographic assessment of the hip. To examine the role that cell cycle control genes may play in this process, we investigated the steady state levels of CDC2 protein and RNA during myogenesis of L6E9 rat myoblasts. Myotonic dystrophy type 1 (DM1) is a neurologic disorder with known cardiac involvement, including left ventricular systolic dysfunction (LVSD), heart failure (HF), atrioventricular and intraventricular conduction system disease, and sudden death. A 61-year-old woman with a gastric antral ulcer scar had a lesion that showed a submucosal tumor-like appearance on endosonography, which proved at resection to represent dense submucosal fibrous tissue. In our institution, for this kind of patients we considered transaxillary (TAx) approach as second choice and transapical (TAp) or transaortic (TAa) as last routes. Serial myocardial enzymes and electrocardiograms confirmed acute non-transmural myocardial infarction.

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Observed handoffs that took place within the clinical unit did not consistently align with the ideal-type routine, yet this variation did not necessarily lead to exceptions. The examination included assessment of visual acuity (VA), retinoscopy, subjective refraction, direct ophthalmoscopy, slit-lamp biomicroscopy and intraocular pressure (IOP). Results: Only 55 of 974 persons requested a rehabilitation measure. Flies carrying mutations that reduce insulin signaling have a growth deficiency phenotype similar to that seen in mice with disruptions of genes encoding insulin-like growth factors (IGFs) or the IGF-I receptor. In contrast, nuclear SNPs can detect bottlenecks followed by rapid recovery, although bottlenecks involving reduction of less than half the population are generally detected with low power unless extensive genetic information from ancient individuals is available. Initially the pseudoaneurysm was successfully treated with covered coronary stent-grafts, but rebleeding occurred 1 mo later due to the brittleness of the artery. Furthermore, the crystalline inclusion complex of clobazam with DM-beta-CyD was obtained by heating of the coprecipitate in vacuo at 120 degrees C for 1 h. Mutagenicity, metabolism and DNA adduct formation of 6-nitrochrysene in Salmonella typhimurium. The case reveals key insights into the progression and complications of lymphomas with GI tract involvement. Today, small bowel transplantation is an experimental treatment.

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Cardiac diseases, particularly coronary artery disease and its risk factors, are associated with the majority of perioperative complications in patients undergoing major noncardiac surgery. Proliferative retinopathy can be arrested with laser photocoagulation. The MAGE genes encode certain tumor-associated antigens recognized by cytotoxic T lymphocytes. This may be due to the greater reach of laparoscopic instruments and camera in the lower abdomen/pelvis. When properly interpreted, ultrasound images of the gastrointestinal wall can provide potentially useful diagnostic information. Therefore, increased AR ligand sensitivity as well as locus-specific chromatin alterations contribute to basal gene expression of a subpopulation of specific AR target genes in androgen-independent PCa cells. Further investigation, such as induction of cytokine genes into effector cells to maximize the in vivo anti-tumor activity, combination of active immunization (tumor vaccine) and adoptive immunotherapy (10) would be definitely required for utilization of adoptive immunotherapy for lung cancer. These findings give causal support to recent correlative data obtained by functional magnetic resonance imaging studies indicating a differential role of SI in spatial and temporal discrimination learning.

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CCDs exhibit dynamic ranges up to 50,000:1, very high quantum efficiency, and ultralow noise. Based on this model, we explored the ability of Ig to balance complement activation versus control in a pig-to-primate cardiac xenotransplantation model in which the binding of xenoreactive antibodies of the recipient to graft blood vessels and the activation of complement cause hyperacute rejection. Doses of 250 mg/kg body weight and 500 mg/kg body weight protected the mice against maximal electroshock seizure, and delayed the onset time of seizures induced by isonicotinic hydrazide acid. Ninety-four patients with advanced cancer completed the Greek version of the Impact of Events Scale-Revised (IES-R-Gr), the Anxiety subscale of the Greek Hospital Anxiety and Depression Scale, and the Preparatory Grief in Advanced Cancer Patients (PGAC) scale. Clinical course of multiple sclerosis: A nationwide cohort study.

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Broad-spectrum behaviour therapy and the treatment of agoraphobia. This is a first step toward predicting milk fat response to changes in nutrient supply. Biochar applied at an appropriate rate can avoid increasing NH3 volatilization dramatically in rice paddy soil. This study aimed to investigate the change in choroidal thickness and volume in eyes with untreated CSC. Biphasic waveforms have similar or greater efficacy at cardioverting atrial and ventricular arrhythmias at lower energy levels than monophasic waveforms, and cause less ST depression following defibrillation of ventricular fibrillation. Proteomic studies on receptor for advanced glycation end product variants in idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. This study reveals the suitability of BC for nerve gap bridging over a period of 16 fenofibrate 160 mg tablet 1 tablet weeks with functional recovery to comparable extent as the autologous nerve graft despite impaired histomorphometric parameters. Some cost-containment policies are thought to increase noncompliance.

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The isolation and structure of a phytoalexin, malvone A (2-methyl-3-methoxy-5,6-dihydroxy-1,4-naphthoquinone) is reported. The results of such combined computational and experimental screening approach led to the identification of two high-potency inhibitors: Suramin and NF023, both symmetric divalent molecules hosting two naphthalene-trisulfonic acid heads. Presently, treatments for xerostomia only target symptoms, as an active therapy method has not been established. Can sonography replace splenoportovenography in evaluation of patients with portal hypertension?. Despite a significant amount of research on automating neuron reconstructions from image stacks obtained via microscopy, in practice most data are still collected manually.

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We describe a case of a 34years old man with GAS pharyngitis complicated by acute myopericarditis who presented with chest pain, ST segment elevation on electrocardiogram, and elevated cardiac biomarkers. Serum fructosamine assay in the evaluation and follow-up of diabetics. Due to the overuse of antibiotics in livestock as a growth-promoting agent, the emergence of multi-antibiotic resistant bacteria is becoming a concern. Recently, we have shown that a decellularized dermal matrix preproduced by the self-assembly approach could be used as a template to further obtain self-assembled skin substitute using a decellularized dermal template (SASS-DM) in vitro. Germline mutations of FP/TMEM127 were associated with pheochromocytoma but not paraganglioma and occurred in an age group frequently excluded from genetic screening algorithms.

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However, the diagnosis between infantile hemangiomas and other vascular tumors, whether benign or malignant, may be difficult. Rapid simultaneous determination of amines and organic acids in citrus using high-performance liquid chromatography. Two cases of a painful os intermetatarseum in athletes are reported. Using an ARF fusion protein, we show that both G beta gamma and G alpha s interact with the small GTPase ARF, an interaction that is regulated by nucleotide binding. Nonradioactive in situ hybridization showed increased expression of messenger RNA for type I and III procollagen and transforming growth factor-beta1 in normal and diabetic wounds, whereas ultrastructural examination showed a marked reorganization of collagen fibrils. Dopamine-containing neurons have been implicated in reward and decision making. We describe here a general assay for colorimetric detection of amplified DNA. Analysis of the prevalence of previously described antibody profiles to these accessory gene products was carried out. Analysis of the mechanical properties of the left ventricle in patients with aortic valve disease.

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Bowel preparation may be an important adjunct to ERAS in rectal surgery. Increased gastric movements due to reserpine were completely inhibited by atropine and vagotomy, moderately inhibited by hexamethonium and diphenhydramine, and only weakly inhibited by l-phenylephrine, l-isoproterenol, phentolamine, propranolol, metiamide, and methysergide. Lesions in the glandular fundus observed on initial examination had healed in 2 of 3 foals, and of the 6 foals with glandular mucosal lesions on reexamination, 5 had developed lesions since the initial examination.(ABSTRACT TRUNCATED AT 250 WORDS). Cases in which the X-ray resulted in a change in management were prilosec 20 mg side effects further reviewed to determine whether administration of tPA could have resulted in potential patient harm. Our findings may contribute to understanding the neural correlates of susceptibility for affective disorders. Most ESD lesions are endoscopically visible, especially if the esophageal mucosa is sprayed with iodine, allowing for directed biopsy. In the kidney, activin delays branching of the ureter bud and reduces the number of secondary branches. Physical incompatibility of sulfonamide compounds and polyionic solutions.

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Because of this tissue specificity, we have postulated a role for it as a mechanism for binding and possibly eliminating excess estrogen in the male. We have constructed replication-defective human adenovirus (Ad) type 5 vectors containing the gene for the Cre recombinase from bacteriophage P1 under control of the human cytomegalovirus immediate-early promoter (AdCre). We present three models by which the DTC may influence GLP-1 activity and thereby determine the zone of mitosis. Roll-plate Alone Does Demonstrate Colonization in Silicone Neonatal Catheters. Various tissues of common winkles, Littorina littorea (L.), experimentally exposed to cadmium (Cd) chloride were examined using light and electron microscopy and their elemental composition determined by X-ray microanalysis and histochemistry. Clinical observation of misoprostol on induction in late pregnancy. In this condition, a device can contribute to a photocurrent without bias. The low positive and negative predictive values of the assays suggests that they were of limited diagnostic benefit in the population sampled. Micro-MRI could be used for serial investigation in terms of flow measurements and detection of thrombosis.

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Patient group seeks overhaul of FDA clinical trial system in court. The use of bacteriophages appears to be a safer alternative for the control of bacterial infections. To examine the prognostic significance of postoperative morbidities in patients with ovarian cancer treated with neoadjuvant chemotherapy and interval surgical debulking. Skull and mandible formation in the cuckoo (Aves, Cuculidae): contributions to the nomenclature in avian osteology and systematics. The chimerism of the rostromedial part of the cerebellum allows the analysis of the origin of the various cerebellar cell types. A novel surgical approach to cardiac autotransplantation in complex cardiac sarcoma resection. The vast majority of theoretical and numerical studies examine density fluctuations at the short length scale focusing exclusively on spherical cavities. Disruption of the gene encoding the 78-kilodalton subunit of the peripheral arm of complex I in Neurospora crassa by repeat induced point mutation (RIP). It is especially noteworthy that the observed trends did not semiquantitatively converge until about 50 picoseconds into the simulations, suggesting that validation studies for protein calculations based on energy minimizations or short simulations should be viewed with caution.

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Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis. Each pool was treated with peptide ligand library beads (PLLBs) to remove high abundance proteins by affinity and thus enrich low abundance proteins. Adjustment for area and individual-level socio-economic characteristics explained the differences for all outcomes except anxiety, psychological ill-health, heart attack and men being overweight. Immunohistological and histological findings in the temporal artery in polymyalgia rheumatica. This can be prevented provided the severity of the retinopathy is recognised pre-operatively and treated appropriately by photocoagulation either before surgery or shortly afterwards. Adapting and Evaluating a Rapid, Low-Cost Method to Enumerate Flies in the Household Setting. Humoral autoimmunity plays an important role in the pathogenesis of two forms of hypoglycemia. The photopic spectral sensitivity of a dichromatic teleost fish (Perca fluviatilis). Full-length 86-kDa SPC3 with an intact carboxyl terminus was found only in bovine chromaffin granules. Progress in the histomorphometry of the microcirculatory system.

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Retrospective analysis of 133 fully ambulant clinical outpatients treated with PBT alone or PBT with/without second-line TT, with/without TCM. Urinary glycoprotein patterns from leukemic patients and from healthy donors were found to be identical, when the detection was carried out with the same quantities of protein. Kinetic analysis suggested that pentobarbitone brought about the inhibition by competing with the diacylglycerol diolein and that mepivacaine and bupivacaine competed with the phospholipid phosphatidylserine used in the assay. To investigate induction of matrix metalloproteinases (MMPs) during mechanical compression of hypertrophic scars. The primary end point was the concentration of plasma ethanol (detection limit 2.2 mmol/L (10 mg/100 mL)), measured every 30 minutes for three prazosin medication psych hours while feet were submerged in a washing-up bowl containing the contents of three 700 mL bottles of vodka.

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This study evaluates the activities of the Japanese Cleft Palate Foundation from 1993 to 2003 in southern Vietnam. Postmortem studies often indicate a pathologic association of increased NRG1 expression or signaling with this illness. Mechanosensing by the primary cilium: deletion of Kif3A reduces bone formation due to loading. We further show that micromolar concentrations of imatinib abrogate multiple signal transduction pathways implicated in RA pathogenesis, including mast cell c-Kit signaling and TNF-alpha release, macrophage c-Fms activation and cytokine production, and fibroblast PDGFR signaling and proliferation. In the absence of definitive studies relating radioiodine dose to outcomes, selection of a dose of radioiodine to treat metastatic thyroid carcinoma is problematic, and several approaches have been noroxin generic name used. The objective of this study was to evaluate the role and benefits of endoscopic ultrasonography (EUS) in the management of postoperative intra-abdominal fluid collections after attempted curative surgery for abdominal cancer. The questionnaire was modified based on the physician feedback, and the revised version was distributed to 2,497 primary care physicians affiliated with two of the seven sites participating in Rewarding Results, a national evaluation of quality target and financial incentive programs. However, current TEVGs do not address the diverse anatomic requirements of individual patients.

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