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Alrest (Clonazepam)
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Alrest

Alrest is one of the products that belong to the bensodiazepine group and have a strong sedative effect. Alrest helps to stop convulsions and epileptic seizures. It is widely used among people with severe panic attacks and anxiety caused by depression treatment.

Other names for this medication:
Alrest, Azpax, Cleps, Cloam, Clodep, Clonark, Clonatrac, Clonaxyl, Clonazepam, Clonix, Clonopam, Clopam, Clotweet, Cloze, Clozep, Clozipam, Clozorix, Cozil, Easyfeel, Ection, Eminaz, Epcon, Epicloz, Epitril, Epizam, Escitapax, Esitor, Ezinite, Jbcloz, Meloprax, Nazee, Nexclo, Norep, Nozim, Nupam, Ozepam, Petril, Prasilex, Prasilife, Repam, Revozip, Rivotril, Sezolan, Zeficar, Zepamax, Zicam, Zozep

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Zebeta, Neoral, Albenza, Mircette, Deltasone, Aygestin, Temovate, Terramycin, Depoxit, Pantopep, Zinimet, Alfacip, Amloray, Srivasmine, Ketosh, Lumbril,

Also known as: Clonazepam

Description

Alrest (clonazepam) is a benzodiazepine. It is thought that clonazepam works by enhancing the activity of certain neurotransmitters in the brain. Clonazepam is also a seizure medicine, also called an anti-epileptic drug.

Alrest is used to treat certain seizure disorders (including absence seizures or Lennox-Gastaut syndrome in adults and children.

Alrest is also used to treat panic disorder (including agoraphobia) in adults.

Dosage

Your doctor will probably start you on a low dose of Alrest and gradually increase your dose, not more often than once every 3 days.

Alrest can be habit-forming. Do not take a larger dose, take it more often, or take it for a longer period of time or in a different way than prescribed by your doctor. Take Alrest exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Alrest may help control your condition, but will not cure it. It may take a few weeks or longer before you feel the full benefit of Alrest. Continue to take Alrest even if you feel well. Do not stop taking Alrest without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood, If you suddenly stop taking Alrest, you may experience withdrawal symptoms such as new or worsening seizures, hallucinating (seeing things or hearing voices that do not exist), changes in behavior, sweating, uncontrollable shaking of a part of your body, stomach or muscle cramps, anxiety, or difficulty falling asleep or staying asleep. Your doctor will probably decrease your dose gradually.

Overdose

Symptoms of clonazepam overdosage, like those produced by other CNS depressants, include somnolence, confusion, coma and diminished reflexes.

Treatment includes monitoring of respiration, pulse and blood pressure, general supportive measures and immediate gastric lavage. Intravenous fluids should be administered and an adequate airway maintained. Hypotension may be combated by the use of levarterenol or metaraminol. Dialysis is of no known value.

Flumazenil, a specific benzodiazepine-receptor antagonist, is indicated for the complete or partial reversal of the sedative effects of benzodiazepines and may be used in situations when an overdose with a benzodiazepine is known or suspected. Prior to the administration of flumazenil, necessary measures should be instituted to secure airway, ventilation and intravenous access. Flumazenil is intended as an adjunct to, not as a substitute for, proper management of benzodiazepine overdose. Patients treated with flumazenil should be monitored for resedation, respiratory depression and other residual benzodiazepine effects for an appropriate period after treatment. The prescriber should be aware of a risk of seizure in association with flumazenil treatment, particularly in long-term benzodiazepine users and in cyclic antidepressant overdose. The complete flumazenil package insert, including CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, should be consulted prior to use.

Flumazenil is not indicated in patients with epilepsy who have been treated with benzodiazepines. Antagonism of the benzodiazepine effect in such patients may provoke seizures.

Serious sequelae are rare unless other drugs or alcohol have been taken concomitantly.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Alrest Wafer dosage information

Side effects

The most common side effects associated with Alrest are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Before taking Alrest, tell your doctor or pharmacist if you are allergic to it; or to other benzodiazepines (such as diazepam, lorazepam); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain type of eye problem (narrow angle glaucoma), a certain blood disorder (porphyria), liver disease, kidney disease, lung/breathing problems, mental/mood problems (such as depression, thoughts of suicide), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol).

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

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Randomised or quasi-randomised trials that included anterior vaginal repair for the treatment of urinary incontinence. Carotid artery stenting (CAS) has been advocated as an alternative to endarterectomy. The microbiota is known to modulate the host response to influenza infection through as-yet-unclear mechanisms. I note that the short duration of addictive rewards leads to negative emotions that accelerate the learning cycle, but cortical reconfiguration in recovery should also inform our understanding of addiction. Cardiac myxomas may present as solitary lesions or in association with the Carney complex. Our results demonstrate that sMIC impairs NKG2D-mediated immunity against pancreatic carcinoma by directly diminishing cytotoxicity of gammadelta T cells and NK cells.

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We found that on days when participants meditated, they responded with greater mindfulness to daily events, which accounted for the beneficial effects of meditating on psychological outcomes. Relationship between salivary histatin 5 levels and Candida CFU counts in healthy elderly. In particular, it is unclear why some, but not all, patients benefit from blockade of TNF. Higher-order human telomeric G-quadruplex DNA metalloenzymes enhance enantioselectivity in the Diels-Alder reaction. The baculovirus Autographa californica nuclear polyhedrosis virus contains an element known as homologous region 5 (hr5) which is an enhancer of delayed-early viral gene expression. Our review covers the following topics relating to cellulose synthesis: genetics, biochemistry, ultrastructure, growth conditions, and ecological considerations as they relate to the diversity of microbes capable of synthesizing this abundant, unique polymer--cellulose. Effects of glucosamine derivatives and uronic acids on the production of glycosaminoglycans by human synovial cells and chondrocytes. ABC supplies classification: a managment tool of costs in nursing. Systolic blood pressure response to exercise in type 1 diabetes families compared with healthy control individuals. Enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC respectively) remain extracellular while colonizing the gut mucosa by attaching and effacing mechanism.

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Factors associated with finishing status for dogs competing in a long-distance sled race. These results suggest that N-ras oncogene plays an important role in human leukemogenesis. A comprehensive phylogeny of Neurospora reveals a link between reproductive mode and molecular evolution in fungi. Primary cutaneous anaplastic large cell lymphoma with leg involvement: a case report and review of 11 cases. Upon further cultivation of MAC up to 28 days, LPS-induced IL-1 beta levels remained very low, but IL-6 levels increased again reaching that of blood MO, and TNF-alpha continued to rise reaching levels up to 30-fold higher than in blood MO. SRSF1 facilitates cytosolic DNA-induced production of type I interferons recognized by RIG-I. Based on these results, the ZVI-based anaerobic digestion process of this work could be easily integrated with the conventional chemical phosphorus removal process in wastewater treatment plant to form a cost-effective and environment-friendly approach, enabling maximum resource recovery/reuse while achieving enhanced methane production in wastewater treatment system. Detection and identification of human pathogenic Leishmania and Trypanosoma species by hybridization of PCR-amplified mini-exon repeats. Subjective ratings of the restructuring process and the feeling of suddenness were obtained on trial-by-trial basis. QPCR-based and array-based analyses of matched cDNAs confirmed cross platform (array-qPCR) transferability.

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Systemic exposure of Paracetamol (acetaminophen) was enhanced by quercetin and chrysin co-administration in Wistar rats and in vitro model: risk of liver toxicity. The findings emphasize the importance of psychiatric nurses assessing health-promoting lifestyles comprehensively in persons with serious mental illnesses and facilitating changes to improve both physical and mental health. Welfare reform and the decline in the health-insurance coverage of children of non-permanent residents. Identifying factors that contribute to emotional reactions to voices is essential for developing effective psychological interventions. In general, examining more pixels in the stereo view results in more ambiguous correspondences. The human glucocorticoid receptor (GR) mediates most of the biologic effects of GC: cytosolic GR binds GCs and is capable to bind to glucocorticoid response elements in DNA and either transactivate or transrepress genes depending on the tissue and cell type. BEHAB (brain enriched hyaluronan binding) is expressed in surgical samples of glioma and in intracranial grafts of invasive glioma cell lines. However, whereas early results have led many to hypothesize a benefit of TEVAR in uncomplicated patients, the natural history of TEVAR after the treatment of TBAD has yet to mature.

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