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Alrest (Clonazepam)

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Alrest is one of the products that belong to the bensodiazepine group and have a strong sedative effect. Alrest helps to stop convulsions and epileptic seizures. It is widely used among people with severe panic attacks and anxiety caused by depression treatment.

Other names for this medication:
Alrest, Azpax, Cleps, Cloam, Clodep, Clonark, Clonatrac, Clonaxyl, Clonazepam, Clonix, Clonopam, Clopam, Clotweet, Cloze, Clozep, Clozipam, Clozorix, Cozil, Easyfeel, Ection, Eminaz, Epcon, Epicloz, Epitril, Epizam, Escitapax, Esitor, Ezinite, Jbcloz, Meloprax, Nazee, Nexclo, Norep, Nozim, Nupam, Ozepam, Petril, Prasilex, Prasilife, Repam, Revozip, Rivotril, Sezolan, Zeficar, Zepamax, Zicam, Zozep

Similar Products:
Zebeta, Neoral, Albenza, Mircette, Deltasone, Aygestin, Temovate, Terramycin, Depoxit, Pantopep, Zinimet, Alfacip, Amloray, Srivasmine, Ketosh, Lumbril,

Also known as: Clonazepam


Alrest (clonazepam) is a benzodiazepine. It is thought that clonazepam works by enhancing the activity of certain neurotransmitters in the brain. Clonazepam is also a seizure medicine, also called an anti-epileptic drug.

Alrest is used to treat certain seizure disorders (including absence seizures or Lennox-Gastaut syndrome in adults and children.

Alrest is also used to treat panic disorder (including agoraphobia) in adults.


Your doctor will probably start you on a low dose of Alrest and gradually increase your dose, not more often than once every 3 days.

Alrest can be habit-forming. Do not take a larger dose, take it more often, or take it for a longer period of time or in a different way than prescribed by your doctor. Take Alrest exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Alrest may help control your condition, but will not cure it. It may take a few weeks or longer before you feel the full benefit of Alrest. Continue to take Alrest even if you feel well. Do not stop taking Alrest without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood, If you suddenly stop taking Alrest, you may experience withdrawal symptoms such as new or worsening seizures, hallucinating (seeing things or hearing voices that do not exist), changes in behavior, sweating, uncontrollable shaking of a part of your body, stomach or muscle cramps, anxiety, or difficulty falling asleep or staying asleep. Your doctor will probably decrease your dose gradually.


Symptoms of clonazepam overdosage, like those produced by other CNS depressants, include somnolence, confusion, coma and diminished reflexes.

Treatment includes monitoring of respiration, pulse and blood pressure, general supportive measures and immediate gastric lavage. Intravenous fluids should be administered and an adequate airway maintained. Hypotension may be combated by the use of levarterenol or metaraminol. Dialysis is of no known value.

Flumazenil, a specific benzodiazepine-receptor antagonist, is indicated for the complete or partial reversal of the sedative effects of benzodiazepines and may be used in situations when an overdose with a benzodiazepine is known or suspected. Prior to the administration of flumazenil, necessary measures should be instituted to secure airway, ventilation and intravenous access. Flumazenil is intended as an adjunct to, not as a substitute for, proper management of benzodiazepine overdose. Patients treated with flumazenil should be monitored for resedation, respiratory depression and other residual benzodiazepine effects for an appropriate period after treatment. The prescriber should be aware of a risk of seizure in association with flumazenil treatment, particularly in long-term benzodiazepine users and in cyclic antidepressant overdose. The complete flumazenil package insert, including CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, should be consulted prior to use.

Flumazenil is not indicated in patients with epilepsy who have been treated with benzodiazepines. Antagonism of the benzodiazepine effect in such patients may provoke seizures.

Serious sequelae are rare unless other drugs or alcohol have been taken concomitantly.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Alrest Wafer dosage information

Side effects

The most common side effects associated with Alrest are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Before taking Alrest, tell your doctor or pharmacist if you are allergic to it; or to other benzodiazepines (such as diazepam, lorazepam); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain type of eye problem (narrow angle glaucoma), a certain blood disorder (porphyria), liver disease, kidney disease, lung/breathing problems, mental/mood problems (such as depression, thoughts of suicide), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol).

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

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Cognitive-behavior therapy (CBT) for Social Phobia is effective in both group and individual formats. Ten patients in the same Turkish family were evaluated by ophthalmologic, audiologic, physical, radiologic, genetic, serologic, and biochemical examinations. Women with paroxysmal SVT and normal menses exhibit a cyclical variation in the occurrence of the arrhythmia with their menstrual cycle. The compound eyes of the mesopelagic eupausiid Thysanopoda tricuspidata were investigated by light-, scanning-, and transmission electron microscopy. Effect of the porosity on the fracture surface roughness of sintered materials: from anisotropic to isotropic self-affine scaling. PML is caused by reactivation of latent JC virus, leading to the death of myelin-producing oligodendrocytes typically with a rapidly fatal outcome. The present study demonstrates that chromosomal markers found in direct tumor preparations can become undetectable in cell culture at variable rates presumably because of overgrowth of normal cell components in the culture. Cross-resistance was selected by glycopeptides alone or serially by beta-lactams and glycopeptides. To test this possibility, the effects of intraperitoneal (i.p.) administration of CCK-8S, at doses that had previously been shown to inhibit food intake, were investigated on water intake in rats trained to make operant responses for water reinforcements.

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Randomised or quasi-randomised trials that included anterior vaginal repair for the treatment of urinary incontinence. Carotid artery stenting (CAS) has been advocated as an alternative to endarterectomy. The microbiota is known to modulate the host response to influenza infection through as-yet-unclear mechanisms. I note that the short duration of addictive rewards leads to negative emotions that accelerate the learning cycle, but cortical reconfiguration in recovery should also inform our understanding of addiction. Cardiac myxomas may present as solitary lesions or in association with the Carney complex. Our results demonstrate that sMIC impairs NKG2D-mediated immunity against pancreatic carcinoma by directly diminishing cytotoxicity of gammadelta T cells and NK cells.

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Most mesangium infiltrating cells were macrophages and T-lymphocytes. We report the preparation of a non-polymer coated superparamagnetic nanoparticle that is stable and biocompatible both in vitro and in vivo. Gradient-based source and mask optimization in optical lithography. Case-control study on the treatment of Hawskins type II fractures of talar neck with minimally invasive or traditional approach. Weanling male rats fed a low magnesium diet for 14 days were protected from audiogenic seizures by administration of phenobarbital and diphenylhydantoin. Recent advances and research in the etiology and clinical treatment of orofacial pain and temporomandibular disorders are reviewed. The evolutionary theory was tested by comparing the steady-state behavior it generated on concurrent schedules to the description of steady state behavior provided by modern matching theory. Surgical databases are now a fundamental part of clinical practice and research but have only been commonplace in the past decade or so. Our study showed that, although conventional and tissue Doppler imaging methods could not determine any effect, two-dimensional speckle-tracking echocardiography revealed the favourable effects of high-dose cholecalciferol on cardiac mechanics, implying the importance of vitamin-D supplementation in children with chronic kidney disease. Bed rest after spinal anesthesia did not prevent the occurrence of headache and increased the incidence of patients experiencing a backache and, therefore, is not recommended.

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The rodent malaria parasite Plasmodium chabaudi chabaudi shares many features with human malaria species, including P. Dendrimers are well-defined chemical polymers with a characteristic branching pattern that gives rise to attractive features such as antibacterial and antitumor activities as well as drug delivery properties. Carrier transport dynamics in the QDSSCs were studied using the intensity modulated photocurrent/photovoltage spectroscopy technique, from which transport and recombination time constants could be derived. The effect of systemic amantadine sulfate on malondialdehyde and total thiol levels in rat corneas. Even so, this system has proven to be cumbersome with questionable cost-effectiveness. The role of DJ-1 in the pathogenesis of endometriosis was investigated. Dissection of the HLA association with multiple sclerosis in the founder isolated population of Sardinia.

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We found that on days when participants meditated, they responded with greater mindfulness to daily events, which accounted for the beneficial effects of meditating on psychological outcomes. Relationship between salivary histatin 5 levels and Candida CFU counts in healthy elderly. In particular, it is unclear why some, but not all, patients benefit from blockade of TNF. Higher-order human telomeric G-quadruplex DNA metalloenzymes enhance enantioselectivity in the Diels-Alder reaction. The baculovirus Autographa californica nuclear polyhedrosis virus contains an element known as homologous region 5 (hr5) which is an enhancer of delayed-early viral gene expression. Our review covers the following topics relating to cellulose synthesis: genetics, biochemistry, ultrastructure, growth conditions, and ecological considerations as they relate to the diversity of microbes capable of synthesizing this abundant, unique polymer--cellulose. Effects of glucosamine derivatives and uronic acids on the production of glycosaminoglycans by human synovial cells and chondrocytes. ABC supplies classification: a managment tool of costs in nursing. Systolic blood pressure response to exercise in type 1 diabetes families compared with healthy control individuals. Enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC respectively) remain extracellular while colonizing the gut mucosa by attaching and effacing mechanism.

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Factors associated with finishing status for dogs competing in a long-distance sled race. These results suggest that N-ras oncogene plays an important role in human leukemogenesis. A comprehensive phylogeny of Neurospora reveals a link between reproductive mode and molecular evolution in fungi. Primary cutaneous anaplastic large cell lymphoma with leg involvement: a case report and review of 11 cases. Upon further cultivation of MAC up to 28 days, LPS-induced IL-1 beta levels remained very low, but IL-6 levels increased again reaching that of blood MO, and TNF-alpha continued to rise reaching levels up to 30-fold higher than in blood MO. SRSF1 facilitates cytosolic DNA-induced production of type I interferons recognized by RIG-I. Based on these results, the ZVI-based anaerobic digestion process of this work could be easily integrated with the conventional chemical phosphorus removal process in wastewater treatment plant to form a cost-effective and environment-friendly approach, enabling maximum resource recovery/reuse while achieving enhanced methane production in wastewater treatment system. Detection and identification of human pathogenic Leishmania and Trypanosoma species by hybridization of PCR-amplified mini-exon repeats. Subjective ratings of the restructuring process and the feeling of suddenness were obtained on trial-by-trial basis. QPCR-based and array-based analyses of matched cDNAs confirmed cross platform (array-qPCR) transferability.

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Genotypic resistance was measured by sequencing the reverse transcriptase gene from plasma HIV-1 RNA. To conduct a policy review of the regulations related to food advertising on television aimed at children. Age-related changes in P2 receptor mRNA of rat cerebral arteries. Left atrial posterior wall and pulmonary vein refractory periods are associated with atrial fibrillation inducibility in a swine model. a purposive sample of 17 Australian parents took part in the broader study. This silencing is efficacious and long-lived, as it is passed to subsequent generations in insect cell culture. All seven tested cytokines (Transforming Growth Factor (TGF) alpha, TGFbeta1, -beta2 and -beta3, IGF 1, Platelet Derived Growth Factor A (PDGF A), basic Fibroblast Growth Factor (bFGF) exhibited higher expression in the adult wounds than at the ages p0 and p3. Interestingly, p43 is also secreted to induce proinflammatory genes.

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Additional experiments with mutant viruses with combinations of IE genes deleted revealed that the ICP27-dependent mechanism of NF-kappaB activation may be augmented by functional ICP4. Treatment of rheumatoid arthritis (RA) with disease-modifying anti-rheumatic drugs (DMARDs), either synthetic (sDMARDs) or biologic agents (bDMARDs) has significantly improved disease outcome. Coping and positive perceptions in Irish mothers of children with intellectual disabilities. Our findings suggested that targeting PKM2 could effectively improve the efficacy of radiotherapy. Uptake by primary breast carcinoma was significantly correlated with the presence of GRP-Rs as assessed by means of IHC. To quantitatively evaluate dose conformity achieved using Gamma Knife radiosurgery, compare results with those reported in the literature, and evaluate risk factors for complications. Trends in the Management of Small Renal Masses: A Survey of Members of the Endourological Society. The metal is probably bonded to the allylic system from the same face as the nucleophile. 32 degrees C) was found to be about 120 with the LC-adsorbed membrane. Reverse shoulder arthroplasty combined with a modified latissimus dorsi and teres major tendon transfer for shoulder pseudoparalysis associated with dropping arm.

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Systemic exposure of Paracetamol (acetaminophen) was enhanced by quercetin and chrysin co-administration in Wistar rats and in vitro model: risk of liver toxicity. The findings emphasize the importance of psychiatric nurses assessing health-promoting lifestyles comprehensively in persons with serious mental illnesses and facilitating changes to improve both physical and mental health. Welfare reform and the decline in the health-insurance coverage of children of non-permanent residents. Identifying factors that contribute to emotional reactions to voices is essential for developing effective psychological interventions. In general, examining more pixels in the stereo view results in more ambiguous correspondences. The human glucocorticoid receptor (GR) mediates most of the biologic effects of GC: cytosolic GR binds GCs and is capable to bind to glucocorticoid response elements in DNA and either transactivate or transrepress genes depending on the tissue and cell type. BEHAB (brain enriched hyaluronan binding) is expressed in surgical samples of glioma and in intracranial grafts of invasive glioma cell lines. However, whereas early results have led many to hypothesize a benefit of TEVAR in uncomplicated patients, the natural history of TEVAR after the treatment of TBAD has yet to mature.

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molesta adults exhibited ovipositional preference for nonbearing peach trees over nonbearing apple trees in close-range choice tests conducted in the field, regardless of the larval host origin. Resequencing the sulfotransferase SULT1 gene provides new insights, while illuminating challenges that lie ahead for pharmacogenomics. We included randomised controlled trials (RCTs) that compared antioxidant vitamin or mineral supplementation (alone or in combination) to placebo or no intervention, in people with AMD. Inhibitory effects of 1,25(OH)2D3 on the proliferation of hepatocellular carcinoma cells through the downregulation of HDAC2. Valorizing guava (Psidium guajava L.) seeds through germination-induced carbohydrate changes. Web of Knowledge, Ovid MEDLINE, CINAHL, PsycINFO, British Nursing Index and PubMed databases were searched. Using the curvilinear projection model can improve the quality of large-field ET reconstruction, but its computational complexity further exacerbates the processing time. However, the care including the conditions for parental participation was driven by the terms of the staff, routines focusing on the medical-technical care and environment, and budgetary constraints. E Sakazakii is a cause of invasive infection with high death rates in neonates. However, studies on normal values of liver stiffness in healthy subjects are still lacking.

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DeCamp: declining use of surgical therapy for early stage non-small cell lung cancer in the United States. Nine test specimens were taken from the circumferential midsubstance of each meniscus, at three circumferential and three axial positions. Bone marrow-derived mesenchymal stromal cells (BM-MSCs) are considered the gold standard for stem cell-based tissue engineering applications. Surgical endoscopy versus gynecologic minimal invasive surgery-. Survival difference was compared using Kaplan-Meier analysis and multivariate Cox regression analysis. Participants were 38,410 apparently healthy men who completed a comprehensive baseline health examination between 1970 and 2001.

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Despite national organizations producing large volumes of research and clinical guidelines, India has not yet introduced a formal HTA programme. Sublaminar wire migration into the medulla oblongata: a case report. Experimental studies suggest that radiation-induced brain injury can be successfully mitigated and treated with several well established drugs in wide clinical use which exert neurontin 100mg tablet their effects by blocking pro-inflammatory cytokines and reactive oxygen species. Tetraspanin CD151 as a target for antibody-based cancer immunotherapy. Cancer Health Empowerment for Living without Pain (Ca-HELP): effects of a tailored education and coaching intervention on pain and impairment. Inclusion/exclusion criteria were applied by 2 independent reviewers.

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