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Adapalene is used to treat acne. Adapalene is in a class of medications called retinoid-like compounds. It works by stopping pimples from forming under the surface of the skin. Adapalene has the unique ability to inhibit keratinocyte differentiation and decrease keratin deposition.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Luvox, Depakote, Amaryl, Zithromax, Ceftin, Ileveran, Cetag, Algyfree, Uriflox, Glyson, Biaxsig, Divinerv,


Adapalene is a third-generation topical retinoid primarily used in the treatment of acne. Adapalene is a gel used for the treatment of acne (blackheads, whiteheads and pimples) of the face, chest or back. Adapalene gel is a clear gel that powers deep inside your pores to control the buildup that leads to acne. It helps prevent the formation of new acne lesions, and can also help get rid of lesions already present. Adapalene works under the skin surface to unclog pores and clear up pimples. Adapalene is also known as Adapalene, Adapen, Adaferin. Generic name of Adapalene is Adapalene.


It is very important that you use this medicine only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause irritation of the skin.

Do not apply this medicine to windburned or sunburned skin or on open wounds.

Do not use this medicine in or around the eyes, lips, or inside of the nose. Spread the medicine away from these areas when applying. If the medicine accidently gets on these areas, wash with water at once.

Apply the medicine to clean, dry areas of the skin affected by acne. Rub in gently and well. Wash your hands afterwards to remove any medicine that may remain on them.

To help clear up your acne completely, it is very important that you keep using this medicine for the full time of treatment , even if your symptoms begin to clear up after a short time. If you stop using this medicine too soon, your acne may return or get worse.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage form (gel): For acne: Adults and teenagers—Apply a small amount as a thin film once a day, at least one hour before bedtime. Apply the medicine to dry, clean areas affected by acne. Rub in gently and well. Children—Use and dose must be determined by your doctor.


If you overdose Adapalene and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Adapalene dosage information

Side effects

The most common side effects associated with Adapalene are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Studies of this medicine have been done only in adult patients, and there is no specific information comparing use of adapalene in children up to 12 years of age with use in other age groups. In teenagers, adapalene is not expected to cause different side effects or problems than it does in adults.

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In contrast, the effective in vivo transduction capacity of Ad5/35 warrants further development of this vector for the treatment of head and neck cancer. Exposure to monoterpenes was assessed by determining monoterpenes in air and verbenols in urine by gas chromatography using flame ionization detection. Those genes were knocked down by siRNA to determine their requirement for supporting cell proliferation and to measure resulting changes in the larger network of gene expression. To evaluate the health-related quality of life (HRQoL) and functional capacity in relation to glycemic control among older home-dwelling primary care patients. It is caused by the presence of autoantibodies directed against desmoglein, a glycoprotein that plays a critical role in cell-cell attachment. Relationship between stage, site and morphological characteristics of pelvic endometriosis and pain. As very strong agreement has been reported between bispectral index (BIS) values measured from the occipital and frontal skull areas, we compared BIS values measured from central and parietal areas with those from frontal area to investigate whether BIS is really a topographically dependent or topographically independent variable. A channel-resolved approach coupled with magnet-captured technique for multianalyte chemiluminescent immunoassay. Mechanistically, hypothalamic stem/progenitor cells contributed greatly to exosomal microRNAs (miRNAs) in the cerebrospinal fluid, and these exosomal miRNAs declined during ageing, whereas central treatment with healthy hypothalamic stem/progenitor cell-secreted exosomes led to the slowing of ageing. Recently, the relationship between PSP and frontotemporal dementia (FTD) has been recognized, which includes clinical, pathological, biochemical and genetic features.

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Expansion of Kolarik model for tensile strength of polymer particulate nanocomposites as a function of matrix, nanoparticles and interphase properties. In other instances, mutations have indicated new functions for particular molecular domains. A measuring system evaluating a Point Spread Function generated in an ultrasonographic image by scanning a spherical target was developed. EVALUATION OF THE I-STAT PORTABLE CLINICAL ANALYZER FOR MEASUREMENT OF IONIZED CALCIUM AND SELECTED BLOOD CHEMISTRY VALUES IN ASIAN ELEPHANTS (ELEPHAS MAXIMUS). ATPlopyruvatelo conditions triggered fatty acid biosynthesis and the formation of cytoplasmic lipid droplets. Transcriptional silencing was transient, independent of DNA methylation, and associated with recruitment of Argonaute 2 (AGO2) to a non-coding RNA (ncRNA) transcript that overlaps the PR gene promoter.

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Trends in mortality from coronary heart and cerebrovascular disease in Switzerland, 1969-87. Dysthyroid optic neuropathy (DON) is a severe manifestation of thyroid eye disease (TED) that can result in permanent vision loss. ELISA inhibition test using monoclonal antibody specific for Treponema pallidum as the serologic test for syphilis. A layer transfer technique was developed to sequentially stack floating opal films of different sphere sizes, resulting in opaline hetero photonic crystals. They present the objectives of nursing intervention, pre and post operative measures to prevent pulmonary complications, early identification of clinical signs of respiratory failure, and treatment. Moreover, the studied biosensor exhibited high sensitivity, good reproducibility, and long-term stability. We have applied the technique of fluorescence in situ hybridization (FISH) directly on archival Wright stained bone marrow slides obtained from a patient who developed acute myelogenous leukaemia (AML) following allogeneic bone marrow transplantation (BMT) for chronic myelogenous leukaemia (CML). The aim of this study is to compare morphofunctional characteristics of the left ventricle (LV) in IO hypertensive subjects, normotensive subjects (hereafter, hypertensives and normotensives), and never-treated sustained hypertensives. Isothermal titration calorimetry confirmed the binding constants derived from emission titrations.

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Many of these risks are well known and include issues such as infiltration, extravasation, phlebitis and pain. The cat appears to symbolize a woman, so mistreatment of cats in combination with sexually motivated burglaries should be considered an important prognostic sign. Mutation of PPP2R1A: a new clue in unveiling the pathogenesis of uterine serous carcinoma. The effects of tolbutamide were quantitatively similar to that found after the elevation of intracellular cAMP. Patients who had their primary tumours located in the medial or central part of the breast had an increased incidence of mediastinal and pleural recurrences respectively. The Wheelchair Use Confidence Scale: Italian translation, adaptation, and validation of the short form. In contrast, it was not detected in the genome of nonpathogenic free-living leptospires. The effects of salicylate on the expression of cyclooxygenases, and on prostaglandin E(2) biosynthesis were examined in human peripheral blood mononuclear cells. We describe three cases of aorto-ostial lesions with recurrent restenosis after multiple modalities of percutaneous treatment, including sirolimus-eluting stent implantation in all cases and intravascular brachytherapy in one case.

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Our results reinforce the necessity to screen hepatitis C virus in all Senegalese blood transfusion centres. An overview of autonomic regulation of parotid gland activity: influence of orchiectomy. There was a follow-up of the dietary intake during 3 working days through direct observation, as well as an assessment of anthropometrical and biochemical parameters, a record of symptomatology related data, and a QoL assessment through the EORTC QLQ-C30 questionnaire. However, widely used fecal blood tests yield frequent false-negative and false-positive results that lower screening effectiveness and raise program costs. Comparison of the samples revealed that children with an average utterance length four to five morphemes produced significantly longer utterances in the home setting. PPARdelta is present in EBs but did not compensate for the lack of PPARgamma in terminal differentiation. Data on kidney transplant outcomes for pediatric patients with end-stage renal disease (ESRD) secondary to anti-neutrophil cytoplasmic antibody glomerulonephritis (ANCA GN), particularly granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), is limited.

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Seroconversion to aMPV was detectable from 10 to 11 days post inoculation. The cases of 61 patients with surgically confirmed epidermal inclusion cysts were reviewed, and 13 patients were found to have ruptured cysts. Constraints that nursing program administrators encounter in promoting faculty change and development. Orbital blowout fractures are uncommon but important injuries for physical therapists to recognize. The association of nephrologic care and survival in patients with diabetes mellitus and chronic kidney disease is unknown. Actigraph analysis of diurnal motor fluctuations during dopamine agonist therapy. Determination of metal dusts in aerosols using x-ray fluorescence. Killing of the organisms, however, was significantly decreased in sham-exposed, but not smoke-exposed, rats ingesting EtOH. We find that injunctive social norms drive the system to the boundaries of phase space, whereas rarity-based conservation priorities drive the system to the interior. The band gap and the optical absorption coefficient of semiconductor nanocrystalline powder can be controlled by its fabricating techniques.

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PPAR delta may inhibit the proliferation of CRC cells and increase the number of cells in G1 phase, without any function in cell apoptosis. Relevant statistics (independent t-test, correlation analysis and hierarchical multiple regressions) were used. The genotoxic potential of formocresol was assessed by comet assay on human peripheral blood lymphocytes and in vivo micronucleus in mice. Depolarized cells were increased, and apoptosis-related proteins, such as Bax, Bcl-2, cleaved caspase-9, cleaved caspase-3 and cleaved ploy ADP-ribose polymerase, were activated. However, little is known about exercise-related epigenetic processes in the horse zyvox cost . Preliminary findings concerning the influence of immunosuppressive drugs. With continued culture, the injured spheroids were found to disaggregate after intensive 131I-TNT-1 therapy (e.g. Directly administered antiretroviral therapy for HIV-infected drug users does not have an impact on antiretroviral resistance: results from a randomized controlled trial. Both underwent successful surgical repair 4 to 5 days after admission, but received postoperatively 1 week of inhaled nitric oxide therapy for persistent pulmonary hypertension.

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Primary care of the HIV patient: standard practice and new developments in the era of managed care. Extrapulmonary manifestations, such as reductions in skeletal muscle and physical inactivity, are important clinical features of patients with chronic obstructive pulmonary disease (COPD), and might depend on the severity of COPD. Information about the new techniques necessary to use with these implants has so far been scarce. It was stated that the earliest and most expressed changes of biochemical values were observed in the lymphatic system, thus pointing to its important role in the resorption nizoral vs t gel and transport of the metabolic products from ischaemic myocardium. Only patients with a follow-up time that exceeded 12 months were enrolled.

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