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Actiblok (Metoprolol)
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Actiblok

Actiblok is a beta-blocker used to treat chest pain (angina), heart failure, and high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This drug works by blocking the action of certain natural chemicals in your body (such as epinephrine) that affect the heart and blood vessels. This lowers heart rate, blood pressure, and strain on the heart.

Other names for this medication:
Actiblok, Actocard, Asoprol, Betaloc, Betaone, Blumeta, Cadmet, Dutoprol, Intramet, Macsart, Mepol, Metapro, Metin, Metocare, Metofin, Metolar, Metolex, Metomac, Metoprolol, Metozest, Metpure, Metscore, Metzok, Nexovas, Powermet, Sitelol, Supermet, Telidin, Teliprolol, Toprol, Translol, Vasomet, Vinicor, Vivalol

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Also known as: Metoprolol

Description

Metoprolol is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. A lower blood pressure can reduce the risk of strokes and heart attacks.

Metoprolol is also used to treat severe chest pain (angina) and lowers the risk of repeated heart attacks. It is given to people who have already had a heart attack. In addition, metoprolol is used to treat patients with heart failure.

This medicine is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain metoprolol. It may not be specific to Actiblok. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Your dose may need to be changed several times in order to find out what works best for you.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of food you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should first check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many patients feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, strokes, or kidney disease.

Swallow the extended-release capsule and tablet whole. Do not crush, break, or chew them.

If you cannot swallow the extended-release capsule:

You may open it and sprinkle the contents over a small amount (teaspoonful) of soft food (including applesauce, pudding, or yogurt). Swallow the mixture within 60 minutes. Do not store for later use. You may also use a nasogastric tube to give the medicine. Mix the contents of the opened capsule with water into a syringe. Gently shake the mixture for about 10 seconds, then flush it through the tube. Rinse the tube with water until all of the medicine is washed out.

Take the tablet or extended-release tablet with a meal or just after you eat. You may break the extended-release tablet into two pieces, but swallow the two pieces whole and do not crush or chew them.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For acute heart attack or heart failure: For oral dosage form (extended-release capsules): Adults—At first, 25 milligrams (mg) once a day for 2 weeks. Your doctor may adjust your dose as needed. However, the dose is usually not more than 200 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 25 milligrams (mg) once a day for 2 weeks. In patients with severe heart failure, the starting dose is 12.5 mg once a day. Your doctor may adjust your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 50 milligrams (mg) every 6 hours for 2 days. Then, 100 mg 2 times a day. The medicine will be started in the hospital. Children—Use and dose must be determined by your doctor. For chest pain: For oral dosage form (extended-release capsules): Adults—At first, 100 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 100 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 100 milligrams (mg) per day, given in two divided doses. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day. Children—Use and dose must be determined by your doctor. For high blood pressure: For oral dosage form (extended-release capsules): Adults—At first, 25 to 100 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day. Children 6 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 1 milligram (mg) per kilogram (kg) of body weight once a day. The first dose should not be more than 50 mg once a day. Your doctor may adjust your dose as needed. Children younger than 6 years of age—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 25 to 100 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day. Children 6 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 1 milligram (mg) per kilogram (kg) of body weight per day, given as a single dose. The first dose should not be more than 50 mg per day. Children younger than 6 years of age—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 100 milligrams (mg) per day, given as a single dose or in divided doses. Your doctor may adjust your dose as needed. However, the dose is usually not more than 450 mg per day. Children—Use and dose must be determined by your doctor. .

Overdose

If you overdose Actiblok and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Actiblok overdosage: fainting, difficulty, breathing or swallowing, swelling of the hands, feet, ankles, or lower legs, lightheadedness.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Actiblok are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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Two structure alphabets are explored, which are represented in Cartesian coordinate space and in torsion angles space respectively. Severe hypertriglyceridemia with a history of treatment failure. Positive expression of ALK gene rearrangement has been considered a molecular subtype of NSCLC, that there are special pathological characteristics and clinical prognosis. This was a pilot study of 15 spinal cord-injured patients with chronic pressure ulcers (PrUs) and nonhealing fistulas treated with PRP. The polyp modeling process takes into account both the gray-level appearance of polyps (intensity profiles) and their geometry (extended Gaussian images). Parvovirus infection during pregnancy has been reported to be associated with spontaneous abortion and fetal loss.

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Effect of conventional mechanical ventilation and jet ventilation on airway pressure in dogs and plastic models with tracheal stenosis. Modelling of promiscuous receptor-Gi/Gs-protein coupling and effector response. This suggested involvement of LTalpha-Troy signaling in mesenchyme-epithelium interactions during hair follicle development. These patients had pain due to the disease progression and complication of chemotherapy and radiation. The future of the work and possible improvements of the method are discussed as well as the educational and therapeutic consequencies. The N-terminal 398 amino acids are all required for the formation of organized nucleocapsid-like particles, since deletion of the central region from amino acids 189-373 completely abolished N-N interaction, and deletion of amino acids 4-188 and 374-492 caused the formation of unstructured aggregates. Proximity Ligation Assay (PLA) is a recently developed technique used mostly in cell and tissue culture that can detect protein-protein interactions in situ. Pulmonary lesions in seven patients with malignancy who were treated with bleomycin were studied at autopsy. Such research is being done with the hope that the knowledge gained will allow the world to better prepare for and respond to future influenza pandemics.

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Investigating the evolution and function of TCP-like genes in a wider group of monocots requires a detailed phylogenetic analysis of all available sequence information and a system that facilitates comparing genetic and functional information. A computer analysis of factors influencing the cerebello-thalamo-cortical signals. The implications of a high stability in reactivity are discussed. The derivation is based on a stochastic path integral technique that reweights paths at different temperatures. These results support the importance of baseline screenings for risk of post-concussion psychological symptoms. Left atrial (LA) function plays an important role in the diastolic function in patients with HCM. Brain tumor models were made and the (10)B concentrations of the tumor, blood, and normal brain from each BDS were analyzed in vivo by use of ICP-AES. At higher expression levels, ClpCP appears to become saturated and unable to prevent the accumulation of ComX.

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There are 110 pseudogenes with overrepresentation in functions associated with carbohydrate metabolism, transcriptional regulation, and pathogenicity. Coaggregates of Treg cells from C57BL/6 mice and islet cells from BALB/c mice were prepared on agarose hydrogel with small round-bottomed wells. Prevalence and epidemiological features of ovine enzootic abortion in Lithuania. TB of Garra rufa were observed on different body location (lips, lateral and ventral areas, forehead, operculum and dorsal-pelvic-pectoral-anal fins). Relevance of bioreactors and whole tissue cultures for the translation of new therapies to humans. This study aimed at evaluating the performance of five laboratory-scale reactors, three UASB and two downflow anaerobic expanded bed (DAEB), fed with saccharose and long chain fatty acids (LCFA) for 410 days. Stage 1 development of a patient-reported experience measure (PREM) for chronic obstructive pulmonary disease (COPD). We have used zebrafish embryos to identify the initiating transcriptional events that occur on activation of human BRAF(V600E) (which encodes an amino acid substitution mutant of BRAF) in the neural crest lineage. The results show that the seismic resistance behavior of the EPS module composite for shear walls performed better than ordinary recycled concrete for shear walls. Combined hepatocellular and cholangiocarcinoma associated with hepatolithiasis: report of a case.

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In Response to Determinants of Olympic Fencing Performance and Implications for Strength and Conditioning Training: Erratum. Stochastic simulations of mixed-lipid compartments: from self-assembling vesicles to self-producing protocells. The effect of the paired stimulation was larger than the summation of the vestibular stimulation during the quiet stance and a leg muscle vibration alone. Differences in maternal behavior and development of their pups depend on the time of methamphetamine exposure during gestation period. In processed food such as tomato puree and ketchup a larger number of caffeoyl-glucose isomers formed through acyl migration reactions were observed. Influence of structural and interfacial properties of microemulsion eluent on albenza tab 200mg chromatographic separation of simvastatin and its impurities. Retreatment with epidermal growth factor receptor inhibitor after initial failure in advanced non-small cell lung cancer. In order to test this hypothesis, we measured the iSP in 21 adult ADHD patients and twenty-one sex- and age-matched healthy controls.

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These amines are extracted from fish by grinding with perchloric acid at -20 degrees C. This has implications for preoperative planning, performing total knee arthroplasty (TKA), and clinical follow-up after TKA surgery using CAS navigation or patient-specific instrumentation. Then, to exploit the higher peak levels attained with IL-2 and the improved trough levels of PEG-IL-2, a combination regimen beginning with bolus IL-2 followed by low dose maintenance PEG-IL-2 was devised and tested for efficacy. Hence, NIC could exacerbate adverse effects of AZA while antioxidants such as resveratrol (RES) could prevent it. A large percentage of arteriovenous haemodialysis angioaccess loop grafts (AVLG) fail within the first year after surgery, the occlusive lesions being found predominantly at the venous anastomosis site. The cloned area defines a region of 50 kb containing a CpG island, found to be selectively methylated in patients expressing the fragile X phenotype. The enzyme was partially purified and characterized and found to exist in the cytoplasm as a 35 kDa monomer. This problem was addressed by using a concanavalin A affinity column to first remove high mannose, hybrid-type and biantennary complex-type N-type glycans before application of the Jacalin columns. This review focuses on the types, fabrication techniques, and stability of colloidosomes. This study investigated the effectiveness of the UDP in the last 6 wk of rehabilitation.

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We conclude to substantial cost savings if management of NHL patients is based on mid-treatment PET scan. The absolute number of granulocytes with the ability to reduce NBT ranged between 0-9737. Remarkably, the mAb possesses the capacity to immunoprecipate HSP70 from promastigote extracts of L. The pleural effusion subsided and has not recurred for the following three years valium 5mg tablet . Animal-assisted therapy for elderly schizophrenic patients: a one-year controlled trial. Synthesis and NMR studies of new DOTP-like lanthanide(III) complexes containing a hydrophobic substituent on one phosphonate side arm.

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Since we had preliminary evidence that this might not be the case, we carried out five small studies in rabbits. There is no difference between PPE and UCP regarding demographic characteristics and medical features. Pretreatment tumor biopsies to assess topoisomerase-I (Topo-I) activity were obtained from 11 patients. To answer this question, ether, short-chain alkanols, and pregnanolone were tested for their ability to induce anesthesia in 20 aquatic species from 7 phyla. This article reviews factors that influence nitrite and leukocyte esterase results obtained from traditional urine dipstick analysis for assessment of urinary tract infections in elderly long-term care residents. Changes in these actin associated proteins are not likely to account for the initial changes in actin MFs. The low-SF preference was largest when the presentation of hybrid faces was brief and reduced as the presentation duration increased. It is necessary to try to operate before the caecum perforates and to do this by decompression, which should for preference be carried out at a site in the transverse colon. This also enables the discriminant evaluation performed in the whole space.

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Disruption of activity in the ventral premotor but not the anterior intraparietal area interferes with on-line correction to a haptic perturbation during grasping. Analysis of sulfated peptides using positive electrospray ionization tandem mass spectrometry. Surgeons should consider this traditional surgery for their patients even if they have high-stage uterovaginal prolapse. We prospectively conducted an open study of the effects of administration of nebulized lidocaine four times daily in 20 patients with asthma who had side effects of exogenous hypercortisolism. Adverse events, such as pain, dyspareunia and decreased sexual interest had a negative impact on QOL. This study demonstrated that ROs can be distinguished reliably from RCCs on the basis of cytologic morphology combined with ancillary studies, including immunostaining with cytokeratin and vimentin antibodies and HCI stain. Nanoparticle-Based Immunochemical Biosensors and Assays: Recent Advances and Challenges. Two new acyclic phenylpropane lignanamides, grossamide K and erythro-canabisine H, and the naphthol glucoside 2,5-dimethyl-3-O-beta-D-glucopyranosylnaphthol, along with six known compounds were isolated from the acetone extract of bark of Hibiscus cannabinus. Procedures based on the use of multiple optical signals from absorption and interference optics for the analysis of the sedimentation velocity and equilibrium behavior of more complex interactions have now been developed. Analysis of the genetic distances performed using principal component analysis revealed strong clustering by location of origin, but not by host Daphnia species.

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