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Aclene (Adapalene)

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Aclene is used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Aclene belongs to a class of medications called retinoids. It works by affecting the growth of cells and decreasing swelling and inflammation.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Medrol, Lamisil, Xeloda, Abilify, Remeron, Lipitor, Rancyl, Fulvicin, Alsartan, Lexcid, Lamostad, Bioglita, Labetalolum, Gabacian,

Also known as: Adapalene


Aclene (adapalene) is a topical medicine (a medication that is applied to the surface of the skin) similar to vitamin A. It helps the skin to renew itself.

Aclene is used to treat severe acne in people who are at least 12 years old. It works by decreasing acne formation.


It is very important that you use this medicine only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause irritation of the skin.

Do not apply this medicine to windburned or sunburned skin or on open wounds.

Do not use this medicine in or around the eyes, lips, or inside of the nose. Spread the medicine away from these areas when applying. If the medicine accidently gets on these areas, wash with water at once.

Apply the medicine to clean, dry areas of the skin affected by acne. Rub in gently and well. Wash your hands afterwards to remove any medicine that may remain on them.

To help clear up your acne completely, it is very important that you keep using this medicine for the full time of treatment , even if your symptoms begin to clear up after a short time. If you stop using this medicine too soon, your acne may return or get worse.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage form (gel): For acne: Adults and teenagers—Apply a small amount as a thin film once a day, at least one hour before bedtime. Apply the medicine to dry, clean areas affected by acne. Rub in gently and well. Children—Use and dose must be determined by your doctor.


If you overdose Aclene and you don't feel good you should visit your doctor or health care provider immediately.


Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Aclene are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Aclene if you are allergic to Aclene components. It is not known whether Aclene will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant or breast-feeding. Do not get Aclene in your eyes or on the inside of your nose or mouth. For the first 2 to 3 weeks of treatment, your skin condition may appear to worsen. This is expected. Do not stop using the medicine during this time. Do not use other medicines on your skin without first discussing it with your doctor. While you are using Aclene, you may use cosmetics. After using cosmetics, thoroughly wash and dry the affected area before applying this medicine. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Aclene. Use a sunscreen if you must be outside. Do not apply it to sunburned skin. Do not stop taking Aclene suddenly.

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We have investigated the pressure- and heat-induced aggregates of equine serum albumin (ESA) from the secondary structural viewpoint using FT-IR spectroscopy. Microbial community composition and function across an arctic tundra landscape. Depressive symptoms were associated with a slightly increased risk of HSV recurrence and increased reports of HIV-related symptoms, whereas stressors were not. However, no studies have been published testing the hypothesis that cytokines can only form polarized clusters at Kupfer-type immunological synapses. We showed that the expression of OsSPL3, OsSPL12, and OsSPL14 were significantly downregulated in Osmtd1 or OsmiR156f overexpressed lines, indicating that OsSPL3, OsSPL12, and OsSPL14 were possibly direct target genes of OsmiR156f. The foam is stable for the duration of the experiment, whereas on Earth the foam starts to disappear immediately. We found PTSD recovery trajectories similar to those in previous studies.

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Altering mealtimes could be a drug-free way to deal with the effects of jet lag and shift work. Genetics of pathways regulating body weight in the development of obesity in humans. In zebrafish, RNAi mediated by miRNAs regulates early development, and in mice embryos that lack the miRNA precursor processor Dicer are nonviable. Our study could not demonstrate any serious effect of PD on subsequent intelligence or on the change in age-specific weight and height percentile of children after non-cardiac surgery. The GFP-tagged N-RAP LIM domain (GFP-N-RAP-LIM) was targeted to the membrane in cells with myofibril precursors and cell-cell contacts. These results suggest that the delayed cardioprotection afforded by MLA is mediated by CGRP via activation of the HO-1 pathway. In contrast to prior 13C-methacetin-breath-test protocols, the LiMAx-test is performed by intravenous body-weight adjusted substrate administration. Mechanism of biofilm-mediated stress resistance and lifespan extension in C. Regeneration capacity of the iliac crest after spongiosa removal in humans--induction by phosphate ceramics?. Our data suggest that trimetazidine may be an important adjunct to prolong ischemic time safely and to decrease lung ischemia-reperfusion injury.

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Cell cultures were derived from benign and malignant salivary gland neoplasms, cultured conservatively, and serially analyzed for epithelial, myoepithelial, and neuroectodermal antigens. Systematic Literature Review and Meta-analysis of Tumor Necrosis Factor-Alpha Experienced Rheumatoid Arthritis. The impact of emotional intelligence and intelligence quotient (IQ) on child anxiety and behavior in the dental setting. Can contrast-enhanced ultrasound with second-generation contrast agents replace computed tomography angiography for distinguishing between occlusion and pseudo-occlusion of the internal carotid artery?. Treatment with anti-CD18 monoclonal antibody slows the expansion of AAA in this experimental model. Regulated RA metabolism may therefore be required in many developing systems. However, this autonomic imbalance is unknown in patients with restrictive cardiomyopathy (RCM) even though they have similar symptoms and poor quality of life as DCM patients have. Patients with LVCM presenting with VT have a common substrate distribution involving predominantly the basal or perivalvular LV, which is often more dramatic on the LV epicardium.

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Edwards and Ryuzo Yanagimachi and the development of modern embryology and human reproduction. There are a number of challenges in translating the growing evidence implicating epigenetics in atherosclerosis to improved therapies for patients. Therefore, we investigated the potential proinflammatory role of CD40 in human and nonhuman primate islets. Three mutations were located in the coiled-coil rod domain of the protein, and one was in the motor domain. Because spinal activation by sensory stimuli has a potential at least equal to that of fist clenching, its feasibility was assessed. During the cultivation cycle, we also followed the organization of actin in the GF11 line and did not detect any significant difference in actin organization from untreated control or exogenous IAA treatment. Dietary diversity was defined according to diet quality index revised. Rat, dog, monkey and human liver microsomal extracts investigated by liquid chromatography electrospray tandem mass spectrometry. The most affected areas are those resulting from recent unregulated urban sprawl in polluted swamp zones or garbage dumps.

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Genetic modification of heterochromatic association and nuclear organization in Drosophila. Potential infectious etiologies of atherosclerosis: a multifactorial perspective. Molecular characterization of bovine rotavirus strains circulating in northern Italy, 2003-2005. In ACM-treated K562 cells, EpoR gene promoter activity completely correlated with EpoR and GATA-1 mRNA levels and the degree of erythroid maturation. Antihypertensive medications can be selected that not only reduce blood pressure but also have beneficial effects in concomitant illness and neutral or positive effects on other cardiovascular risk factors. The use of amplified nucleic acids means that for the first time full characterization of hESC lines can be performed with little time investment and a minimum of material. However, the known cholestatic agent, alpha-naphthylisothiocyanate (ANIT) has never been fully examined for its effect on these processes. Thus all relaxation patterns of the system are determined by these three time scales.

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The prevalence of autism spectrum disorder (ASD) is on the rise. To investigate the topology of the protein in the membrane, in vitro glycosylation assays were conducted using X2 derivatives that contained N-glycosylation sites introduced at the N or C termini of the protein. We examined immunohistochemical changes in the transforming growth factor (TGF)-beta and platelet-derived growth factor (PDGF) in the optic nerve head in an experimentally induced glaucoma model. Mutational analyses further showed that the conserved Cys6 residue of YodB is required for optimal repression in vivo and in vitro while substitution of all three Cys residues of YodB affects induction of azoR1 transcription. Lipid spectrum in fractions of liver cell chromatin from mice after partial hepatectomy. These studies suggest that activation of CK2 mediates the stimulatory effect of TGF-beta1 on type IV collagen gene transcription. In Situ Soft X-ray Spectromicroscopy of Early Tricalcium Silicate Hydration. Chitosan antiviral activity: dependence on structure and depolymerization method. Peripheral blood lymphocytes from those three groups were used to study the induction of micronuclei (MN) by mitomycin C, cyclophosphamide, and quercetin. Thus far, analysis of the processes underlying the epithelial-mesenchymal dysadhesion marking this disease has been limited by the reduced growth and adhesive capabilities of the epithelial cells derived from H-JEB patients.

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Improved conditions of sanitation and hygiene practices are associated with reduced prevalence of stunting in rural India. Comparisons of rates of population growth through time reveal that the invention of agriculture facilitated a fivefold increase in population growth relative to more ancient expansions of hunter-gatherers. Fractional flow reserve (FFR) allows for physiological definition of coronary lesion severity but requires induction of maximal coronary circulation hyperemia with administration of adenosine leading to coronary resistive vessel vasodilatation. In addition, usp45 signal peptide was inserted for the efficient secretion of a tab cozaar 50 mg price in pakistan foreign protein outside cells. Catalpol modulates the expressions of Bcl-2 and Bax and attenuates apoptosis in gerbils after ischemic injury. Health impact assessment as a tool for health promotion and population health. Otherwise, the host will still be able to lay eggs, but its reproduction capacity is diminished. The short-term assessment of stress condition overcomes the limits to stress characterization with long blocks of time and allows to evaluate the behaviour change in real-world settings and also the stress level dynamics. EFS in high-risk patients has been markedly improved by including IVAC in protocol 89-C-41, and excellent results can be achieved with only four cycles of therapy. Studies of change detection have shown that changing the task-irrelevant features of remembered objects impairs change detection for task-relevant features, a phenomenon known as the irrelevant change effect.

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A phase II trial of paclitaxel and carboplatin in women with advanced or recurrent uterine carcinosarcoma. At follow-up, all the fractures had united in the position secured initially by the frame and no patient complained of pain in the sacro-iliac joints. Here, we fill this lacuna by developing a normative cost minimisation model based on Bayesian optimality principles. Further, with the growing recognition of a possible inflammatory basis, the prospects of disease modifying now seem realistic. SSR is a useful option of minimally invasive surgery for an early stage gastric cancer. The protocol works equally well for in vitro cell culture assays and for tissue samples obtained from in vivo experiments. Gait pattern in two rare genetic conditions characterized by muscular hypotonia: Ehlers-Danlos and Prader-Willi syndrome. The results of this study may be used to improve patient care and optimize the procedure of PET/CT examination in a fixation mask.

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Morphological variation in males of Dendrocephalus orientalis (Anostraca: Thamnocephalidae): Implications for species identification. Hand scored ISS by trained personnel may circumvent this problem. This study was designed to measure the effects of increased intracompartmental pressure on skeletal muscle microcirculation, inflammation and cellular injury using intravital videomicroscopy (IVVM) in a clinically relevant small animal model. The fine silk fibers (about 8 microm) were obtained at faster spinning speed, 240 cm min(-1). Crystal structure of dehydratase component HadAB complex of mycobacterial FAS-II pathway. Intracranial chondrosarcoma is a differential diagnosis for intracranial tumors of the skull base.

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The extent of apoptosis by TRAIL is tightly regulated by the expression of these receptors and by downstream signaling. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. Platelet monoamine oxidase (MAO) activity was investigated in 58 subjects. Treatment of rats with vitamin E (400 mg/kg, s.c.) on 4 successive days before injection of PQ prevented only the enhancement of lipid peroxidation. ROBIN is integrated in a sensor-rich environment that aims to continuously monitor physical and psychological wellbeing of older persons living alone. National provider identifier compliance date approaching quickly. We studied 39 patients with unilateral microtia and recorded their skin sensitivity more than how to take crestor 20 mg six months after the last operation. Recognition of the toxic causes of myelopathy, including nitrous oxide exposure, heroin, radiation, various chemotherapeutic agents, liver disease, konzo, lathyrism, and zinc excess, is aided by understanding the typical clinical and imaging features associated with these agents. A report is given about the synthesis of IgG immunoglobulins in the pleural infiltrations. Three patients had unilateral adrenal tumor, and three had bilateral disease.

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