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Aceclofenac

Aceclofenac is an angiotensin-converting enzyme (ACE) inhibitor (ACEI). It exerts a protective effect in DR by decreasing VEGF-to-PEDF ratio (downregulating VEGF and upregulating PEDF). The lowering of VEGF-to-PEDF ratio is significantly correlated with the relief of the vascular damage and was a result of reduced mitochondrial ROS production by increasing uncoupling protein 2 (UCP-2).

Other names for this medication:
Aceclofenac, Acertil, Acerycal, Agulan, Aldoc, Armix, Asyntilsan, Bionoliprel, Biprel, Bipreterax, Cardipen, Coveram, Coverene, Coverex, Covinace, Domanion, Dorover, Indapril, Inopil, Midopril, Noliprel, Pendoril, Pendrex, Percarnil, Perindal, Perindan, Perindo, Perindox, Prestance, Prestarium, Preterax, Prexanil, Prexum, Prindace, Procaptan, Provinace, Reaptan, Stopress, Teraxans, Vectoryl, Vidotin

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Description

Aceclofenac (perindopril) is an ACE inhibitors. ACE stands for angiotensin converting enzyme.

Aceclofenac is used to treat high blood pressure (hypertension) and to prevent heart attack in people with coronary artery disease.

Dosage

Usual Adult Dose for Coronary Artery Disease:

Initial dose: 4 mg orally once a day for 2 weeks, then increase to maintenance dose as tolerated. Maintenance dose: 8 mg orally once a day Use: Treatment of patients with stable coronary artery disease to reduce the risk of cardiovascular mortality or nonfatal myocardial infarction.

Usual Adult Dose for Hypertension:

Initial dose: 4 mg orally once a day Maintenance dose: 4 to 8 mg orally per day in 1 or 2 divided doses Maximum dose: 16 mg/day Comments: In patients treated with a diuretic, consider reducing the diuretic dose prior to starting this drug.

Usual Geriatric Dose for Coronary Artery Disease:

Greater than 70 Years: Initial dose: -Week 1: 2 mg orally once a day -Week 2: 4 mg orally once a day, then increase to maintenance dose as tolerated. Maintenance dose: 8 mg orally once a day Use: Treatment of patients with stable coronary artery disease to reduce the risk of cardiovascular mortality or nonfatal myocardial infarction.

Usual Geriatric Dose for Hypertension:

Initial dose: 4 mg orally per day in 1 or 2 divided doses Comments: Experience with doses above 8 mg is limited; administer with careful blood pressure monitoring and dose titration.

Detailed Aceclofenac dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Aceclofenac are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Do not use potassium supplements or salt substitutes, unless your doctor has told you to.

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Application of two-dimensional spectral surface plasmon resonance to imaging of pressure distribution in elastohydrodynamic lubricant films. The vacuole as central element of the lytic system and sink for lipid droplets in maturing appressoria of Magnaporthe grisea. The cytomorphology of these hepatic tumors in aspiration smears is much less well known. We expressed the dimeric HIgA in Chinese hamster ovary-K1 (CHO-K1) cells. Determinants of osteopenia in male renal-stone-disease patients with idiopathic hypercalciuria. Other HCV transmission episodes have been associated with chromatography (particularly DEAE-Sephadex chromatography) as a separation step carried out to further purify IgG, after cold ethanol fractionation, and it is possible that such a procedure has only a marginal partitioning capacity for infective HCV virions. Protein kinase C-dependent activation of cytosolic phospholipase A2 and mitogen-activated protein kinase by alpha 1-adrenergic receptors in Madin-Darby canine kidney cells. Whether CCL2 protumorigenic activities will be validated, then CCL2 and its receptor CCR2 may be therapeutic targets in cancer. We previously described the differential distribution of gangliosides in adult rat brain as detected by specific antibodies. Prospective studies comparing EUS with percutaneous FNA of adrenal masses are indicated to help delineate the indications and limitations of each technique.

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